2026-04-25 11:29:03非可切割铰链区：CAR-T细胞治疗急性髓系白血病的结构新突破
非可切割铰链区：CAR-T细胞治疗急性髓系白血病的结构新突破【题目】Non-cleavablehingeenhancesavidityandexpansionofCAR-Tcellsforacutemyeloidleukemia【期刊】NatureC...
了解详情非可切割铰链区：CAR-T细胞治疗急性髓系白血病的结构新突破【题目】Non-cleavablehingeenhancesavidityandexpansionofCAR-Tcellsforacutemyeloidleukemia【期刊】NatureC...
了解详情CTLA-4胞质尾融合重塑CAR-T细胞：从trogocytosis机制破局，实现持久抗肿瘤免疫【题目】CTLA-4tailfusionenhancesCAR-Tantitumorimmunity【期刊】NatureImmunology【影响因子】2...
了解详情CAR-T细胞疗效的结构密码：从抗原识别域到载体骨架的全景解析【题目】CAR-Tcellpotency:fromstructuralelementstovectorbackbonecomponents【期刊】BiomarkerResearch【影响因...
了解详情CAR-T细胞联合疗法：突破肿瘤治疗瓶颈的新策略【基础信息】文献信息卡片：【题目】CARTcellcombinationtherapiestotreatcancer【期刊】CancerCell【影响因子】48.8【通讯作者】CarlH.June，宾夕...
了解详情IL-12联合阿霉素驱动T细胞深度穿透实体瘤：突破TIL和CAR-T的实体瘤归巢困境【题目】T-cellHomingTherapyforReducingRegulatoryTCellsandPreservingEffectorT-cellFuncti...
了解详情T细胞与乳腺癌免疫治疗：从TILs生物标志物到CAR-T细胞临床转化的全景综述【题目】T-cell-basedbreastcancerimmunotherapy【期刊】SeminarsinCancerBiology【影响因子】14.5【导语/背景】乳...
了解详情Sortilin介导的MedTAC：mRNA编码溶酶体靶向嵌合体实现膜蛋白快速持久降解[基础信息]文献信息卡片：[题目]Sortilin-MediatedRapid,PreciseandSustainedDegradationofMembranePr...
了解详情KineTAC：模块化细胞因子受体靶向嵌合体拓展胞外蛋白降解的组织特异性边界[题目]Modularcytokinereceptor-targetingchimerasfortargeteddegradationofcellsurfaceandextr...
了解详情细胞外靶向蛋白降解(eTPD)：技术全景梳理与临床转化路径前瞻[题目]Extracellulartargetedproteindegradation:anemergingmodalityfordrugdiscovery[期刊]NatureReview...
了解详情工程化病毒样纳米颗粒（VNP）实现多模式蛋白降解，助力增强肿瘤治疗·【题目】EngineeredVirus-LikeNanoparticlesEnableMultimodalProteinDegradationforEnhancedTumorTher...
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